If IKEA flatpacks have taught us anything, it’s that you need the right number of pieces. Same goes for your nervous system. Researchers investigate how correct neuron numbers are produced using confocal microscopy of the developing fruit fly visual system (pictured). Projections from light-sensing cells (cyan, middle bottom) release the chemical EGF, triggering precursor cells to become neurons (yellow). Precursors are arranged in columns of six, but only five become neurons, the sixth dies. Another cell type – glia (magenta, middle bottom) – also aid neuron development. Using mutant fly larvae whose photoreceptors don’t release EGF and hence neurons are lost, the team showed that restoring EGF restored neurons. But if glia were prevented from responding to the EGF, the neurons didn’t develop. Glia were found to release chemicals triggering neuron development and certain neurons were shown to release chemicals preventing the extra precursor from becoming a neuron. So, complex cell-to-cell signalling controls neuron numbers.
Written by Lux Fatimathas
Image from work by Anadika R Prasad and colleagues
Department of Cell and Developmental Biology, University College London, London, UK
Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
Published in eLife, September 2022
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It’s been so long since i said it but if you live with homophobic/transphobic parents no matter if you’re a minor or a young adult don’t come out <3
For those of you with anxiety
here’s a website that translates the time into hexidecimal colours,
here is a website where you can create your own galaxies
here is a website where you can play flow
here you can interact with organisms in different environments to see how to music changes
here you can play silk which is an interactive generative art designing website.
Here is a website where you can travel along a 3D line into the infinite unkown
here is a website where you can listen to rain with or without music
He loved the roses
even when it's thrones hurt him
for the rose was a sight to behold
and his love unbound
But he forgot that
it would not last forever
until he was left
with nothing but his pain and loss..
By c&p..
Removed/checked all links to make sure everything is working (03/03/23). Hope they help!
Sejda - Free online PDF editor.
Supercook - Have ingredients but no idea what to make? Put them in here and it'll give you recipe ideas.
Still Tasty - Trying the above but unsure about whether that sauce in the fridge is still edible? Check here first.
Archive.ph - Paywall bypass. Like 12ft below but appears to work far better and across more sites in my testing. I'd recommend trying this one first as I had more success with it.
12ft – Hate paywalls? Try this site out.
Where Is This - Want to know where a picture was taken, this site can help.
TOS/DR - Terms of service, didn't read. Gives you a summary of terms of service plus gives each site a privacy rating.
OneLook - Reverse dictionary for when you know the description of the word but can't for the life of you remember the actual word.
My Abandonware - Brilliant site for free, legal games. Has games from 1978 up to present day across pc and console. You'll be surprised by some of the games on there, some absolute gems.
Project Gutenberg – Always ends up on these type of lists and for very good reason. All works that are copyright free in one place.
Ninite – New PC? Install all of your programs in one go with no bloat or unnecessary crap.
PatchMyPC - Alternative to ninite with over 300 app options to keep upto date. Free for home users.
Unchecky – Tired of software trying to install additional unwanted programs? This will stop it completely by unchecking the necessary boxes when you install.
Sci-Hub – Research papers galore! Check here before shelling out money. And if it’s not here, try the next link in our list.
LibGen – Lots of free PDFs relate primarily to the sciences.
Zotero – A free and easy to use program to collect, organize, cite and share research.
Car Complaints – Buying a used car? Check out what other owners of the same model have to say about it first.
CamelCamelCamel – Check the historical prices of items on Amazon and set alerts for when prices drop.
Have I Been Pawned – Still the king when it comes to checking if your online accounts have been released in a data breach. Also able to sign up for email alerts if you’ve ever a victim of a breach.
I Have No TV - A collection of documentaries for you to while away the time. Completely free.
Radio Garden – Think Google Earth but wherever you zoom, you get the radio station of that place.
Just The Recipe – Paste in the url and get just the recipe as a result. No life story or adverts.
Tineye – An Amazing reverse image search tool.
My 90s TV – Simulates 90’s TV using YouTube videos. Also has My80sTV, My70sTV, My60sTV and for the younger ones out there, My00sTV. Lose yourself in nostalgia.
Foto Forensics – Free image analysis tools.
Old Games Download – A repository of games from the 90’s and early 2000’s. Get your fix of nostalgia here.
Online OCR – Convert pictures of text into actual text and output it in the format you need.
Remove Background – An amazingly quick and accurate way to remove backgrounds from your pictures.
Twoseven – Allows you to sync videos from providers such as Netflix, Youtube, Disney+ etc and watch them with your friends. Ad free and also has the ability to do real time video and text chat.
Terms of Service, Didn’t Read – Get a quick summary of Terms of service plus a privacy rating.
Coolors – Struggling to get a good combination of colors? This site will generate color palettes for you.
This To That – Need to glue two things together? This’ll help.
Photopea – A free online alternative to Adobe Photoshop. Does everything in your browser.
BitWarden – Free open source password manager.
Just Beam It - Peer to peer file transfer. Drop the file in on one end, click create link and send to whoever. Leave your pc on that page while they download. Because of how it works there are no file limits. It's genuinely amazing. Best file transfer system I have ever used.
Atlas Obscura – Travelling to a new place? Find out the hidden treasures you should go to with Atlas Obscura.
ID Ransomware – Ever get ransomware on your computer? Use this to see if the virus infecting your pc has been cracked yet or not. Potentially saving you money. You can also sign up for email notifications if your particular problem hasn’t been cracked yet.
Way Back Machine – The Internet Archive is a non-profit library of millions of free books, movies, software, music, websites and loads more.
Rome2Rio – Directions from anywhere to anywhere by bus, train, plane, car and ferry.
Splitter – Seperate different audio tracks audio. Allowing you to split out music from the words for example.
myNoise – Gives you beautiful noises to match your mood. Increase your productivity, calm down and need help sleeping? All here for you.
DeepL – Best language translation tool on the web.
Forvo – Alternatively, if you need to hear a local speaking a word, this is the site for you.
For even more useful sites, there is an expanded list that can be found here.
apparently Rick Astley of all ppl came to the vaccine center today ?!!?!?
and I'm off to go have some cupcakes he left there!?!?
All the torso animated studies.
Fundamental life advice: never trust a product from a youtuber/influencer sponsorship
FOOD
Find your nearest food bank or mission, for food
grocery stores with free samples, bakeries + stores with day-old bread
different fast food outlets have cheaper food and will generally let you hang out for a while.
some dollar stores carry food like cans of beans or fruit
SHELTER
Sleeping at beaches during the day is a good way to avoid suspicion and harassment
sleep with your bag strapped to you, so someone can’t steal it
Some churches offer short term residence
Find your nearest homeless shelter
Look for places that are open to the public
A large dumpster near a wall can often be moved so that flipping up the lids creates an angled shelter to stay dry
HYGIENE
A membership to the YMCA is usually only 10$, which has a shower, and sometimes laundry machines and lockers.
Public libraries have bathrooms you can use
Dollar stores carry low-end soaps and deodorant etc.
Wet wipes are all purpose and a life saver
Local beaches, go for a quick swim
Some truck stops have showers you can pay for
Staying clean is the best way to prevent disease, and potentially get a job to get back on your feet
Pack 7 pairs of socks/undies, 2 outfits, and one hooded rain jacket
OTHER
first aid kit
sunscreen
a travel alarm clock or watch
mylar emergency blanket
a backpack is a must
downgrade your cellphone to a pay as you go with top-up cards
sleeping bag
travel kit of toothbrush, hair brush/comb, mirror
swiss army knife
can opener
A long-term project of mine on this blog is to keep an accurate table of contents for all of the posts I've reblogged: it helps me find posts on specific topics I've reblogged whenever I want, since a tag can sometimes be too much to sift through. Below are links to my google docs with links back to my own blog in case OPs delete or deactivate. I post this in case anyone would like to reference them, since they are now up to date!
Information on General Magic, Spells, Correspondences, and Substitutions
Information on Specific Types of Magic
Information on Astrology (I just wanted this one separate)
Spells, Spreads, Sigils
I hope whoever references these pages finds them useful 😀