A Numbers Game

A Numbers Game

A Numbers Game

If IKEA flatpacks have taught us anything, it’s that you need the right number of pieces. Same goes for your nervous system. Researchers investigate how correct neuron numbers are produced using confocal microscopy of the developing fruit fly visual system (pictured). Projections from light-sensing cells (cyan, middle bottom) release the chemical EGF, triggering precursor cells to become neurons (yellow). Precursors are arranged in columns of six, but only five become neurons, the sixth dies. Another cell type – glia (magenta, middle bottom) – also aid neuron development. Using mutant fly larvae whose photoreceptors don’t release EGF and hence neurons are lost, the team showed that restoring EGF restored neurons. But if glia were prevented from responding to the EGF, the neurons didn’t develop. Glia were found to release chemicals triggering neuron development and certain neurons were shown to release chemicals preventing the extra precursor from becoming a neuron. So, complex cell-to-cell signalling controls neuron numbers.

Written by Lux Fatimathas

Image from work by Anadika R Prasad and colleagues

Department of Cell and Developmental Biology, University College London, London, UK

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in eLife, September 2022

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It’s been so long since i said it but if you live with homophobic/transphobic parents no matter if you’re a minor or a young adult don’t come out <3

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3 years ago

ROSES

He loved the roses

even when it's thrones hurt him

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Tags
4 months ago

Just a bunch of Useful websites - Updated for 2023

Removed/checked all links to make sure everything is working (03/03/23). Hope they help!

Sejda - Free online PDF editor.

Supercook - Have ingredients but no idea what to make? Put them in here and it'll give you recipe ideas.

Still Tasty - Trying the above but unsure about whether that sauce in the fridge is still edible? Check here first.

Archive.ph - Paywall bypass. Like 12ft below but appears to work far better and across more sites in my testing. I'd recommend trying this one first as I had more success with it.

12ft – Hate paywalls? Try this site out.

Where Is This - Want to know where a picture was taken, this site can help.

TOS/DR - Terms of service, didn't read. Gives you a summary of terms of service plus gives each site a privacy rating.

OneLook - Reverse dictionary for when you know the description of the word but can't for the life of you remember the actual word.

My Abandonware - Brilliant site for free, legal games. Has games from 1978 up to present day across pc and console. You'll be surprised by some of the games on there, some absolute gems.

Project Gutenberg – Always ends up on these type of lists and for very good reason. All works that are copyright free in one place.

Ninite – New PC? Install all of your programs in one go with no bloat or unnecessary crap.

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Unchecky – Tired of software trying to install additional unwanted programs? This will stop it completely by unchecking the necessary boxes when you install.

Sci-Hub – Research papers galore! Check here before shelling out money. And if it’s not here, try the next link in our list.

LibGen – Lots of free PDFs relate primarily to the sciences.

Zotero – A free and easy to use program to collect, organize, cite and share research.

Car Complaints – Buying a used car? Check out what other owners of the same model have to say about it first.

CamelCamelCamel – Check the historical prices of items on Amazon and set alerts for when prices drop.

Have I Been Pawned – Still the king when it comes to checking if your online accounts have been released in a data breach. Also able to sign up for email alerts if you’ve ever a victim of a breach.

I Have No TV - A collection of documentaries for you to while away the time. Completely free.

Radio Garden – Think Google Earth but wherever you zoom, you get the radio station of that place.

Just The Recipe – Paste in the url and get just the recipe as a result. No life story or adverts.

Tineye – An Amazing reverse image search tool.

My 90s TV – Simulates 90’s TV using YouTube videos. Also has My80sTV, My70sTV, My60sTV and for the younger ones out there, My00sTV. Lose yourself in nostalgia.

Foto Forensics – Free image analysis tools.

Old Games Download – A repository of games from the 90’s and early 2000’s. Get your fix of nostalgia here.

Online OCR – Convert pictures of text into actual text and output it in the format you need.

Remove Background – An amazingly quick and accurate way to remove backgrounds from your pictures.

Twoseven – Allows you to sync videos from providers such as Netflix, Youtube, Disney+ etc and watch them with your friends. Ad free and also has the ability to do real time video and text chat.

Terms of Service, Didn’t Read – Get a quick summary of Terms of service plus a privacy rating.

Coolors – Struggling to get a good combination of colors? This site will generate color palettes for you.

This To That – Need to glue two things together? This’ll help.

Photopea – A free online alternative to Adobe Photoshop. Does everything in your browser.

BitWarden – Free open source password manager.

Just Beam It - Peer to peer file transfer. Drop the file in on one end, click create link and send to whoever. Leave your pc on that page while they download. Because of how it works there are no file limits. It's genuinely amazing. Best file transfer system I have ever used.

Atlas Obscura – Travelling to a new place? Find out the hidden treasures you should go to with Atlas Obscura.

ID Ransomware – Ever get ransomware on your computer? Use this to see if the virus infecting your pc has been cracked yet or not. Potentially saving you money. You can also sign up for email notifications if your particular problem hasn’t been cracked yet.

Way Back Machine – The Internet Archive is a non-profit library of millions of free books, movies, software, music, websites and loads more.

Rome2Rio – Directions from anywhere to anywhere by bus, train, plane, car and ferry.

Splitter – Seperate different audio tracks audio. Allowing you to split out music from the words for example.

myNoise – Gives you beautiful noises to match your mood. Increase your productivity, calm down and need help sleeping? All here for you.

DeepL – Best language translation tool on the web.

Forvo – Alternatively, if you need to hear a local speaking a word, this is the site for you.

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apparently Rick Astley of all ppl came to the vaccine center today ?!!?!?

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All The Torso Animated Studies.
All The Torso Animated Studies.
All The Torso Animated Studies.
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All The Torso Animated Studies.
All The Torso Animated Studies.
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What to do if you suddenly find yourself homeless

FOOD

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different fast food outlets have cheaper food and will generally let you hang out for a while.

some dollar stores carry food like cans of beans or fruit

SHELTER

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sleep with your bag strapped to you, so someone can’t steal it

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Public libraries have bathrooms you can use

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OTHER

first aid kit

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Information on General Magic, Spells, Correspondences, and Substitutions

Information on Specific Types of Magic

Information on Astrology (I just wanted this one separate)

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